CALL FOR PAPERS Mathematical Modeling of Renal Function Diffusive oxygen shunting between vessels in the preglomerular renal vasculature: anatomic observations and computational modeling
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چکیده
Bruce S. Gardiner, Sarah L. Thompson, Jennifer P. Ngo, David W. Smith, Amany Abdelkader, Brad R. S. Broughton, John F. Bertram, and Roger G. Evans School of Computer Science and Software Engineering, The University of Western Australia, Perth, Australia; Department of Physiology, Monash University, Melbourne, Australia; Department of Pharmacology, Monash University, Melbourne, Australia; and Department of Anatomy and Developmental Biology, Monash University, Melbourne, Australia
منابع مشابه
Diffusive oxygen shunting between vessels in the preglomerular renal vasculature: anatomic observations and computational modeling.
To understand how geometric factors affect arterial-to-venous (AV) oxygen shunting, a mathematical model of diffusive oxygen transport in the renal cortex was developed. Preglomerular vascular geometry was investigated using light microscopy (providing vein shape, AV separation, and capillary density near arteries) and published micro-computed tomography (CT) data (providing vessel size and AV ...
متن کاملCALL FOR PAPERS Renal Hypoxia Renal oxygenation: preglomerular vasculature is an unlikely contributor to renal oxygen shunting
Olgac U, Kurtcuoglu V. Renal oxygenation: preglomerular vasculature is an unlikely contributor to renal oxygen shunting. Am J Physiol Renal Physiol 308: F671–F688, 2015. First published December 10, 2014; doi:10.1152/ajprenal.00551.2014.—The primary aim of this study was to assess the plausibility of preglomerular arterial-tovenous oxygen shunting in the kidney. To this end, we have developed a...
متن کاملRenal oxygenation: preglomerular vasculature is an unlikely contributor to renal oxygen shunting.
The primary aim of this study was to assess the plausibility of preglomerular arterial-to-venous oxygen shunting in the kidney. To this end, we have developed a segment-wise three-dimensional computational model that takes into account transport processes in arteries, veins, cortical tissue, and capillaries. Our model suggests that the amount of preglomerular oxygen shunting is negligible. Cons...
متن کاملThe Bohr Effect Is Not a Likely Promoter of Renal Preglomerular Oxygen Shunting
The aim of this study was to evaluate whether possible preglomerular arterial-to-venous oxygen shunting is affected by the interaction between renal preglomerular carbon dioxide and oxygen transport. We hypothesized that a reverse (venous-to-arterial) shunting of carbon dioxide will increase partial pressure of carbon dioxide and decrease pH in the arteries and thereby lead to increased oxygen ...
متن کاملVascular geometry and oxygen diffusion in the vicinity of artery-vein pairs in the kidney.
Renal arterial-to-venous (AV) oxygen shunting limits oxygen delivery to renal tissue. To better understand how oxygen in arterial blood can bypass renal tissue, we quantified the radial geometry of AV pairs and how it differs according to arterial diameter and anatomic location. We then estimated diffusion of oxygen in the vicinity of arteries of typical geometry using a computational model. Th...
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تاریخ انتشار 2012